Population
All Patients who are admitted to ICU and who are on controlled mechanical ventilation for more than 24 hours are eligible for the study (Screening).
Inclusion Criteria
A patient must meet all the criteria listed below and show readiness to perform the preinclusion test to participate in the trial:
Age ≥ 18 years
Duration of controlled mechanical ventilation ≥ 24h
Availability of a Infinity V500 ventilator (ready to use)
Informed consent according to local regulations
Temperature ≤ 39 °C
Hemoglobin ≥ 6 g/dl
PaO2/FIO2 Ratio ≥ 150 mmHg with PEEP ≤16 cmH2O
Ability to breath spontaneously
Exclusion Criteria
A patient meeting any of the exclusion criteria listed below must be excluded from participating in the trial.
Participation in another interventional trial within the last four weeks before enrollment in this trial
Peripheral neurological disease associated with impairment of the respiratory pump
Muscular disease associated with impairment of the respiratory pump
Instable thorax with paradoxical chest wall movement
Planned surgery under general anesthesia within 72 hours
Difficult airway/intubation
Existing tracheotomy at time of randomization
Expected survival < 72 hours
Home mechanical ventilation or on chronic oxygen therapy
Suspected pregnancy