Additional intraoperative signals are recorded routinely measured and displayed by the anaesthesia machine and the patient monitoring system

Recordings of respiratory and haemodynamic signals in high temporal resolution (sampling rate > 10 Hz): airway flow, volume and pressure (as measured by the anesthesia machine: Dräger Primus) and electrocardiogram and, if available, continuous invasive airway pressure (routine patient monitoring system: Philips MP70). All signals are recorded online using a certified communication port without additional hardware.

• Participating sites: Dresden, Freiburg, Genoa, Istanbul

Before and at the end of surgery, as well as for the following 5 days, blood samples (10 ml) will be collected. The blood samples are stored at minus 80°C for measurement of:

• Inflammatory mediators (e.g. cytokines, chemokines, other inflammatory proteins)
• Markers of lung injury (e.g. angiopoietin-2, surfactant proteins A and D)
• Specific markers of distal organ injury (e.g. cystatin C, NGAL)

• Participating sites: Dresden, Coswig, Aachen